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How is PBC treatment changing?
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How will you rethink your treatment goals to help your patients with PRIMARY BILIARY CHOLANGITIS (PBC)?

Rethink your treatment of PBC by learning about PBC progression and ways to reduce the risk of liver transplant or death for your patients.1,2

REDUCING RISK IN PATIENTS WITH PBC FOR IMPROVED SURVIVAL

Disease progression may occur in “stable”a patients3,b

PBC progression over time

For illustrative purposes only.

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Recent data from the Global PBC Study Groupc suggest updated information around prognostic markers should be considered1,2:

  • The prognostic value of ALP and bilirubin below the ULN
  • Regular assessment of fibrosis
  • a The term “stable” is used to describe PBC patients whose biomarkers have been decreased to thresholds above ULN, but remain persistent and are not increasing.
  • b In a prospective cohort study (N=187; median follow-up of 5.8 years), liver biomarkers for PBC patients improved prominently within the first 3 months of UDCA treatment and then stayed relatively stable (above the ULN) for the following months. Some patients experienced an adverse outcome (ie, liver-related death, liver transplantation, or complications of cirrhosis) despite achieving biochemical response with UDCA.3
  • c The Global PBC Study Group is an international collaboration of 17 centers across Europe and North America that aims to identify reliable surrogate endpoints in PBC using patient data from long-term follow-up cohorts.1
  • ALP, alkaline phosphatase; UDCA, ursodeoxycholic acid; ULN, upper limit of normal.

References:
1. Murillo Perez CF, Harms MH, Lindor KD, et al; the GLOBAL PBC Study Group. Goals of treatment for improved survival in primary biliary cholangitis: treatment target should be bilirubin within the normal range and normalization of alkaline phosphatase. Am J Gastroenterol. 2020;115(7):1066-1074. 2. Murillo Perez CF, Hirschfield GM, Corpechot C, et al; the GLOBAL PBC Study Group. Fibrosis stage is an independent predictor of outcome in primary biliary cholangitis despite biochemical treatment response. Aliment Pharmacol Ther. 2019;50(10):1127-1136. 3. Zhang LN, Shi TY, Shi XH, et al. Early biochemical response to ursodeoxycholic acid and long-term prognosis of primary biliary cirrhosis: results of a 14-year cohort study. Hepatology. 2013;58(1):264-272.